Oxurion Announces Preclinical Data on THR-687 for the Treatment of Diabetic Macular Edema at the 2022 Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
Leuven, BELGIUM, Boston, MA, US – May 3, 2022 – 7:10 PM CET – Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing next generation standard of care ophthalmic therapies, with a clinical stage portfolio in vascular retinal disorders, presented preclinical data from a study evaluating THR-687 for treatment of diabetic macular edema (DME) at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting being held in Denver, Colorado on May 1-4th and virtually on May 11-12th.
Preclinical data shows THR-687s potent inhibition of vascular permeability, inflammation and reactive gliosis in diabetic rats supporting evidence of clinical utility of THR-687 in multiple retinal diseases.
THR-687 is a highly selective pan-RGD integrin antagonist that is initially being developed as a potential first line therapy for DME patients and may have the potential to deliver improved treatment outcomes for patients with wet macular degeneration (wet AMD) and macular edema following retinal vein occlusion (ME-RVO). Targeting RGD-binding integrins is known to affect multiple disease hallmarks such as vascular leakage, inflammation, angiogenesis and fibrosis. The preclinical study investigated the therapeutic potential of THR-687, a potent pan-RGD integrin antagonist, in the streptozotocin (STZ)-induced diabetes rat model.
Following STZ-induced diabetes, different doses of THR-687 (6.7, 16.7 or 75 µg/eye) or its vehicle were administered via 3 consecutive intravitreal injections in both eyes (with 1-week interval, n=7 rats/group). Untreated, non-diabetic rats served as controls (n=5 rats). At 4 weeks after diabetes-induction, the effect of THR-687 was investigated by histological analysis for retinal vascular leakage (using the tracer FITC-BSA), for inflammatory cell activation (Iba1 immunoreactivity) and Müller cell gliosis (vimentin immunoreactivity). Statistical analysis was performed with a one-way analysis of variance using a Bonferroni multiple comparison test.
The updated data shows:
- THR-687 reduced diabetes-induced increases in retinal permeability versus vehicle in a dose-dependent manner. The highest dose (75 µg/eye) completely prevented vascular leakage (p<0.001) while the mid dose (16.7 µg/eye) significantly decreased this pathology by 34 ± 21% (p<0.05) and the low dose (6.7 µg/eye) had no effect.
- All doses of THR-687 also significantly reduced the number of inflammatory cells, as compared to vehicle. Indeed, a reduction of 57 ± 12% was seen after administration of the highest dose (p<0.01), a decrease of 43 ± 19% for the mid dose (p<0.05) and the low dose induced a reduction of 51 ± 13% (p<0.05).
- The highest dose of THR-687 also reduced the diabetes-induced increase in vimentin expression within the Müller cells back to baseline (p<0.05 versus vehicle), whereas no significant differences following injections of the mid or low dose were observed.
RGD-integrin antagonism using THR-687 potently inhibits vascular permeability, inflammation and gliosis induced by STZ in the diabetic rat retina. Given its broad mode of action, THR-687 is a promising drug candidate for the treatment of vision-threatening retinal pathologies and is currently in a Phase 2 clinical trial in DME patients (INTEGRAL - NCT05063734).
- A copy of the ARVO presentation is available under Conferences and Events within the Investors section of the Company’s website.
Oxurion is currently evaluating THR-687 in a two-part Phase 2 clinical trial (“INTEGRAL”) in patients with DME. Part A dose optimization data from the INTEGRAL trial is anticipated this quarter. If successful, the efficacy and safety of THR-687 versus aflibercept (the current standard of care) will be evaluated in Part B of the INTEGRAL Phase 2 clinical trial in both treatment-naïve and treatment-experienced patients with DME with data expected in the second half of 2023.